Improvement of Skin Permeation of Caffeine, a Hydrophilic Drug, by the Application of Water Droplets Provided by a Novel Humidifier Device

Recently, a novel humidifier that sprays water fine droplets equipped with copolymer, poly(3,4-ethylene dioxythiophene)–poly(styrene sulfonate) (PEDOT/PSS) was developed. PEDOT/PSS in the absorbs from environment and releases by heating. In present study, effect of hydration on skin barrier, stratum corneum, first determined application using humidifier. The skin-penetration enhancement model hydrophilic drug, caffeine, also investigated compared conventional water-evaporative More prolonged observed after droplet release than addition, markedly higher permeation caffeine both infinite finite dose conditions. Furthermore, oil/water emulsion containing conditions pretreatment PEDOT/PSS. This device can provide without replenishing water, so it is more convenient for enhancing chemical compounds topical drugs cosmetic formulations.